Do antidepressants prolong the QT interval?
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چکیده
منابع مشابه
An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval
INTRODUCTION Drug-induced prolongation of the QT interval on the electrocardiogram (long QT syndrome, LQTS) can lead to a potentially fatal ventricular arrhythmia known as torsades de pointes (TdP). Over 40 drugs with both cardiac and non-cardiac indications are associated with increased risk of TdP, but drug-drug interactions contributing to LQTS (QT-DDIs) remain poorly characterized. Traditio...
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BACKGROUND Dabigatran etexilate is a pro-drug of the oral reversible direct thrombin inhibitor dabigatran that interacts with the active site in the catalytic domain of the thrombin molecule. OBJECTIVE To assess the electrophysiological effects of therapeutic and supratherapeutic doses of dabigatran etexilate in healthy subjects, a thorough QT study was performed. METHODS In this single-cen...
متن کاملThe sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study
BACKGROUND Empagliflozin is a potent, selective sodium glucose cotransporter 2 (SGLT2) inhibitor in development as an oral antidiabetic treatment. This QT interval study assessed potential effects of empagliflozin on ventricular repolarisation and other electrocardiogram (ECG) parameters. METHODS A randomised, placebo-controlled, single-dose, double-blind, five-period crossover study incorpor...
متن کاملData science identifies novel drug interactions that prolong the QT interval
Drug-induced prolongation of the QT interval on the electrocardiogram (long QT syndrome, LQTS) can lead to a potentially fatal ventricular arrhythmia called torsades de pointes (TdP). 180 drugs with both cardiac and non-cardiac indications have been found to increase risk for TdP, but drug-drug interactions contributing to LQTS (QT-DDIs) remain poorly characterized. Traditional methods for mini...
متن کاملDoes Artesunate Prolong the Electrocardiograph QT Interval in Patients with Severe Malaria?
Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibility of a class effect with the artemisinin derivatives. Serial electrocardiograms were recorded, ...
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ژورنال
عنوان ژورنال: Epidemiology and Psychiatric Sciences
سال: 2013
ISSN: 2045-7960,2045-7979
DOI: 10.1017/s204579601300070x